The Fate of Dystrophin and Some Signs of Apoptosis in the Skeletal Muscle Work-Overloaded in Extension
نویسندگان
چکیده
Rat muscles, soleus and extensor digitorum longus (EDL), were eccentrically electrostimulated at low frequency for 4-24h. The cryostat-sections of these muscles were examined by immunohistochemistry. Numerous muscle fibres were damaged and necrotic. Simultaneously, several preserved fibres were not stained, or stained only discontinuously, with the anti-dystrophin and anti-p-dystroglycan antibody. Apoptotic nuclei (TUNEL-positive) were occasionally noticed within the muscle fibres. Those changes appeared earlier in the EDL than in the soleus.
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